A raft of injuries has hit the Gunners in the last few weeks and it's threatening to derail their potential title challenge.
The likes of Jack Wilshere, Tomas Rosicky and Danny Welbeck were long-term absentees at the club, and were joined by Theo Walcott, Alex Oxlade-Chamberlain and Aaron Ramsey before the international break.
A 2-1 loss to West Brom on Saturday saw that list grow, with midfield duo Francis Coquelin and Mikel Arteta both picking up injuries that will rule them out of the crunch Champions League clash, reports the Mirror.
That will leave Wenger once again short on numbers for their must win game in the Champions League clash with Zagreb.
One player who will be key is Mathieu Flamini, who must stand up and fill the void left by Coquelin’s injury.
The young French midfielder has quickly become key to Arsenal’s play, with him providing the defensive balance to compliment their attacking play.
So far Flamini has not looked capable of replicating that in the side, with him looking unable to replicate Coquelin’s performances in the side.
Arsenal will be hoping he can turn that around if Coquelin is set for a spell on the sidelines.