The former Southampton man says their lack of strength in depth could hinder their chances.
Arsene Wenger’s side have been hit by an injury crisis in the last few weeks, with several of their big stars currently on the treatment table.
That curse continued as they lost Francis Coquelin early in the game against West Brom, with Mikel Arteta replacing him and enduring a torrid afternoon.
And Le Tissier says the defeat has left him questioning whether they have the squad depth to challenge for the title.
“Maybe the injuries threw them out of their stride,” he told Sky Sports.
“It makes me think that perhaps one thing that might stop them winning the title is their strength in depth. With the injuries they’ve got, you look at what they’ve got on the bench to try and change a game and it wasn’t a lot.”
When you compare Arsenal’s squad with fellow challengers Manchester City, it is easy to see where Le Tissier is coming from.
The Gunners may have a number of their stars out, but even when everyone is fit they are still lacking in some key areas.
Defensive midfield is a particular weakness, with the likes of Mathieu Flamini and Mikel Arteta looking struggling to fully cover for Francis Coquelin in the heart of the engine room.