Villa appointed Frenchman Garde earlier this month, and he took charge of his first game before the international break, with a credible 0-0 draw against title favourites Manchester City.
Now, Garde takes his team on the road for the first time, as Villa travel to take on Everton at Goodison Park in a tricky encounter for both sides.
The Toffees have won just one of their last five games, and that came against a woeful Sunderland side - but manager Roberto Martinez will be hoping to enjoy a huge win over another relegation-threatened side.
Striker Romelu Lukaku has been in fine form for Everton this season, and Villa must look to keep the Belgian quiet if they are to get anything out of the game this afternoon.
Ahead of the game, pundit Mark Lawrenson has told BBC Sport that whilst there were promising signs during Garde's debut against Manchester City, he thinks another team will be able to take their chances against a poor Villa side.
Lawrenson believes that Everton will win the game 2-0, with that 0-0 draw against City not enough for him to back Villa to get a result.
"Remi Garde was only in charge of Villa for three days before their draw with Manchester City, and he will not have seen much of his squad over the last week or so because of international call-ups," said Lawrenson. "Garde got off to a good start with a point and a clean sheet, but Villa still did not look like scoring and usually, when you allow the opposition as many chances as City had, then you end up conceding a few goals."
"Everton were solid enough against West Ham in their last game and I just cannot tip Villa to go away and get anything at the moment," he added.