Lovren has not been in the best of form since his arrival from Southampton, but is likely to take the place of Mamadou Sakho.
Sakho suffered a knee injury prior to the international break in the defeat to Crystal Palace and looks set to be sidelined until the New Year, meaning that Lovren is likely to get a run of games in the side.
The Frenchman has impressed since he came into the side in September, while Lovren has not found any sort of good form since his £20 million arrival from Southampton - price reported by the BBC - in the summer of 2014.
He said: “Mama had a really good couple of games and a good start to the season. We played in Rubin Kazan together and were feeling really good.
“But you never know in football – injuries can happen today or tomorrow. So you need to be prepared. I was working hard all the time so I’m ready and looking forward to playing.
“Last year I had a tough year. I didn’t do pre-season with the team and everything was such a rush.
“Everyone, all together, has started better than last year. It was important for me that I had a good pre-season with the team and I’m feeling more comfortable now."
This really needs to be a time when Lovren finds some form. He is going to get a consistent run of games in the side and needs to show just why so much money was spent on him.
He faces a huge test first up when the Reds take on Manchester City on Saturday, where a good defensive effort is going to have to be on show for Jurgen Klopp's side to have any chance of getting a result - unless a switch has flicked when it comes to their goalscoring and they hit a purple patch.
Not much has been seen of Lovren under Klopp so far, though in both games he has started under the recently appointed Reds boss the side have managed to keep a clean sheet. He will hope that run continues from Saturday onwards.