The fixture had been set to feature players from Premier League clubs including Liverpool, Chelsea, Manchester City, and Tottenham Hotspur.
National newspaper Nieuwsblade reported the game had been called off under Government orders.
This is due to an increased terrorism threat, with the report stating the procedure for such action is defined as: "There is a potential and probable threat against the person the group or event that is the subject of analysis."
More specifically it is feared that fugitive Salah Abdeslam - wanted in connection with the Paris terror attacks - could be in Belgium.
Just earlier in the day Belgium defender Jan Vertonghen had been reported by Nieuwsblade discussing how he was looking forward to the friendly, and how important it was the game goes on with no fear.
When there is a specific threat against a game though it is a different matter, and fans around the world will hope this is not a sign of things to come with regard to matches in the future, and Euro 2016, set to take place in France next summer - but it goes without saying that the safety of spectators and players and staff should be sensibly assessed, and in light of ongoing security operations in Belgium, this is a decision which has been taken for the right reasons.
Liverpool's Simon Mignolet, Christian Benteke, Tottenham's Mousa Dembele, Toby Alderweireld, and Mousa Dembele had been among the Premier League stars expected to feature, along with Chelsea's Eden Hazard and Manchester City's Kevin de Bruyne.
England's friendly with France is currently scheduled to go ahead at Wembley as planned.