The former assistant believes his old side will struggle to get the points they need to avoid relegation again.
Wilkins recently left Villa Park alongside Tim Sherwood, who was sacked by the club after a disappointing start to the season.
That run left them rooted to the bottom of the Premier League table, without a win since the opening day of the season, with them hoping new manager Remi Garde can turn things around at the club.
His reign started brightly with a 0-0 draw against Manchester City before the international break, but Wilkins believes they will struggle to avoid relegation regardless of the positive start the Frenchman has made.
“I think it’s extremely difficult for them at the moment [to stay up],” he told BT Sport.
“I think where they find themselves at the moment; it’s going to take a hell of a lot to transfer that into massive points. I think it’s going to be an extremely difficult season for them.”
Given the poor start to the campaign Villa have had, it is hard to see them escaping relegation this season.
The big problem for the side is that they do not look like they have the quality to get them out of their current predicament, with the summer signings not looking good enough so far.
They also have problems at both ends of the pitch, with them looking unlikely to score goals, while also struggling defensively.
Both of those make up for a big problem for Garde and his team, making relegation seem inevitable at this stage of the season.
However, given the time left in the season, there are many things, which could change before the end of the campaign.