Those two have formed a strong partnership at the heart of the Gunners' defence this season, something that has contributed to the side’s strong defensive record so far.
The duo are very much the first choice pairing at the Emirates, with the likes of Gabriel Paulista and Chambers having to play back up roles so far.
The England defender is currently converting from a full back into a centre back for the side, and says Mertesacker and Koscielny are constantly offering him advice.
“Per [Mertesacker] always gives me advice and Laurent [Koscielny] is the same,” he told the Daily Mail.
“I feel I can go up to them and ask them anything and learn from them. I watch them in games all the time, learning and it is helping me get better and better.'
The young defender has also insisted that he is not frustrated by his lack of opportunities this season.
The defender enjoyed an appearance laden first year after joining from Southampton last season, making a host of appearances and his England debut.
This year has been a different tale for him, with him currently only enjoying 324 minutes of competitive action for the side.
That has likely be a disappointing lack of game time for Chambers, but he insists that he is happy to just continue his on-going education at the Emirates.
“I feel I have learned so much over the last two years and I am happy,” he added.
“At the moment, I have changed position to centre back. I'm not getting so much game time but I am still working in training and trying to fight for my place. I'm not down or anything.”