The Frenchman is out for three months with an ankle injury.
West Ham were dealt a massive blow this week after it was confirmed that their star player Dimitri Payet was set to miss the next three months of action after picking up an injury in the Premier League fixture with Everton at the weekend.
The Frenchman was scythed down by Everton midfielder James McCarthy and suffered ankle ligament damage that will see him out of action until the New Year.
It is of course a huge worry for West Ham fans as the attacking midfielder has been the pick of the Premier League buys so far this season and he will be dearly missed by the Hammers faithful.
But one former Hammer believes West Ham are well equipped to overcome his absence.
Tony Cottee played for West Ham in two separate spells in his career, scoring nearly 150 goals in his time with the club and nowadays he works mainly as a TV pundit for Sky Sports.
"For me, West Ham have the strongest squad they have had since the turn of the century. Manuel Lanzini is a different sort of player, but I think he has the talent to step up and take on Payet’s playmaking role in the team.
"I think this West Ham team have the ability to push on and stay in the top half of the table. Losing Payet will not help the cause, but hopefully the squad is strong enough to cope."
Lanzini has also proven to be an excellent buy for West Ham, after being brought in on loan from Al Jazira.
If he and the likes of Victor Moses, Mauro Zarate and seemingly forgotten recent signing Michail Antonio can step up in Payet's absence than West Ham should be able to cope without their talismanic Frenchman.