A week later Leicester take on van Nistelrooy's old club for whom he was playing when he set the amazing record and Vardy has the very realistic prospect of needing to score in that match to set a brand new record in his own right.
A football fairytale
It is the kind of fairytale scenario that only football could throw up.
When Vardy dispatched his penalty in the 2-1 over Watford last time out he became the first Englishman to score in nine consecutive Premier League matches.
It has left him with just van Nistelrooy, one of the best strikers of his generation, to overtake as he is the only player in Premier League history to score in 10 consecutive games.
That came way back in the 2002/3 season as Sir Alex Ferguson's exciting side beat Arsenal to the title by just five points.
How Vardy could surpass Golden Boot winner
His goals that season earned him recognition across Europe as he scooped the Golden Boot with 25 league goals, one more than another legendary striker and adversary, Thierry Henry.
Obviously there is work still to be done but who would bet against it given the season the electric forward is enjoying?
Providing he survives games against Spain and France without sustaining serious injury he will rejoin Leicester for their trip to Newcastle.
The Magpies have been struggling all season under Steve McClaren and Vardy will fancy his chances of matching van Nistelrooy's tally on that big St James' Park pitch where he can use his pace to full effect.
Then come Louis van Gaal's stuttering Manchester United who will be under pressure to win against an unexpected rival for a Champions League place.
With that in mind and calls from fans for the Red Devils to be more attacking it may leave space for Vardy to get his record-breaking goal against the club that has held it for so long.