Liverpool suffered their first defeat under Jurgen Klopp, and unfortunately it came in front of their home fans at Anfield.
The Reds lost 2-1 to Crystal Palace, and the game was marred further from a home side perspective by an injury to Mamadou Sakho.
The Frenchman was withdrawn after 40 minutes, and Liverpool looked a shakier side without him.
Sakho has been arguably Liverpool's best player since Jurgen Klopp took over from Brendan Rodgers in mid-October, with the centre-back playing with a renewed focus and aggression.
His replacement was Dejan Lovren, who had recently been dropped from the side, and he did little to state his case for a regular place in the loss to Palace.
The worrying thing for Liverpool is that the injury to Sakho could mean Lovren gets more opportunities, with the extent of the Frenchman's knee injury still to be established.
Alberto Moreno had a disappointing game at left-back, while Clyne undid the positive aspects of his game with a silly decision to shoot from 40 yards out with Liverpool chasing the game.
It is a game nobody in the Liverpool defence will remember fondly, including Sakho, but the former PSG ace is the only one to see his reputation boosted, as the team's loss just highlighted how important he has become.
If Liverpool are going to be without him for any substantial amount of time, then they need Lovren to show a sharp improvement, or at least just get to January when Klopp can bring in a new signing to bolster his options - something he may be considering whether Sakho is healthy or not.