The West Ham playmaker came off injured against Everton on Saturday.
If it is a lengthy injury for the 28-year-old, though, the rest of Slaven Bilic's squad will have to step up.
Much has been made of West Ham's newfound strength in depth this season and Bilic's side are certainly a class above last campaign's team under Sam Allardyce.
But the focal point so far has been Payet and, should the Hammers go just two games without him, it'll be the ultimate test of the strength of their squad.
The Frenchman has been vital to West Ham's hopes so far this term and there's no overstating how much his absence could be felt at Upton Park.
With that comes an opportunity for others, however. How will Bilic rotate if Payet's injury does keep him out beyond the international break and who will create West Ham's chances in the 28-year-old's stead?
The Hammers enjoyed a very good summer transfer window - but now could be the time to prove just how good it really was.