Villa moved to appoint Frenchman Garde on Monday evening, just hours before a 3-1 defeat away at Tottenham Hotspur - a result which leaves Villa bottom of the table with just one win this season.
Garde, 49, didn't take charge of the game against Spurs, but will make his Premier League bow as a manager on Sunday - and he faces a daunting task as Manchester City arrive at Villa Park.
Manuel Pellegrini's side sit top of the Premier League with 25 points from 11 games, and the Blues may well be the favourites to lift the title ahead of Arsenal.
City will be looking for another three points on Sunday, in a game which could see former Aston Villa hero Fabian Delph make his return to Villa Park, with a hostile reception expected.
Now, pundit Mark Lawrenson has told BBC Sport that he believes City will win the game 2-0 on Sunday, and also stated that, having seen Villa in action against Tottenham on Monday, Garde will face a tough task turning Villa's fortunes around this season.
"Aston Villa's defeat by Tottenham on Monday showed there is nothing wrong with their effort or application, but they are just not good enough," said Lawrenson. "Villa seem to lose their way far too easily in games and struggle to score goals, so keeping them up will be a massive job for new manager Remi Garde."
"His appointment is a massive gamble, and this is a very difficult game to start with, especially with Manchester City's ability to exploit any space with their width and pace. City were very impressive against Sevilla in the Champions League in midweek. They had a plan and had a real go, and anything like the same sort of performance will be too much for Villa," he added.