The Gunners boss was disappointed with the defensive display put in against Bayern Munich in midweek.
The Gunners take on their north London rivals on Sunday in what is sure to be a big game for both sides, with the duo currently competing at the top end of the Premier League table.
Arsenal will be particularly keen to put in a good performance and banish the memory of their 5-1 defeat to Bayern Munich in midweek.
And Wenger believes that the mental approach of his side will be of vital importance.
“I believe that in the Premier League we have a strong confidence and focus and that is what we want to reproduce on Sunday against Tottenham,” he told arsenal.com.
“As always, it is a derby. It is always a game where the commitment and nervous force will be important. It is not easy [to recover] because it is always a big disappointment [to lose].”
Reflecting on the big loss to Pep Guardiola’s side, Wenger says that failing to replicate their usual defensive solidity contributed to the heavy defeat.
The Gunners were on the back foot for most of the first game at the Emirates, but were solid throughout as they stood firm and Petr Cech put in a top display, with them utilising a counterattacking approach to secure an impressive win.
That strength was missing in the reverse fixture, allowing Bayern to run riot, and Wenger says that had they replicated their first performance, they would have won again.
“If we had our usual defensive performance, we could have repeated what we had done in the first game,” he added.
“We had not our usual defensive performance, especially for the first two goals, where we gave them the goals basically, that is when it is difficult because Bayern is maybe the best team at the moment in Europe.