Tottenham Hotspur players will have played three games in a week by the time they take on Arsenal on Sunday.
Spurs take on Anderlecht on Thursday night, before facing Arsenal on Sunday, meaning they will have played three games in a week.
But Pochettino is not interested in hearing about his team being tired, and says that all his players must ensure that they do not think they have a ready-made excuse, in-case they lose to Arsenal.
"We need to take the schedule and not complain about that," Pochettino said to Sky Sports. "We need to accept the rules, the schedule, we knew the situation before. We're ready to compete.
"It's true this is not the best condition but we need to be ready and we need to take the excuse away from the players - 'Maybe they are tired because they played on Monday?' - no.
"We need to put this idea out of our mind. We're in a very good condition and we are fit and we need to be ready.
"It's more mental than physical, playing every two days, and we're in a very good run - we need to keep focused because we have a very important game."
Spurs’ matches against Anderlecht and Arsenal have the potential to be season defining ones, and they are both greatly important.
Tottenham need to win in the Europa League this evening to stand a good chance of qualifying from their group.
They also will be determined to keep their 10 match unbeaten run going, as they mount of top-four challenge in the Premier League.
Spurs have made a great start to the season, but defeat to Arsenal will kill a lot of the momentum that they have built up.