The former Arsenal forward has backed hosts Bayern to win the Group F encounter at the Allianz Arena in Munich 2-1 and winger Arjen Robben to score first.
“My heart wants to say that I believe we can get a score draw, I'm tempted by Arsenal 0-1 on the handicap and I'd swallow your arm if you offered me a 1-1,” Nicholas wrote on Skysports.com.
“However, I think they'll be hurting from what we did to them at the Emirates and be out for revenge.”
A footnote added: “Charlie predicts: 2-1 and Robben to score first”.
Could Charlie Nicholas’s prediction come true?
Bayern will head into Wednesday evening’s match as favourites, especially as they are at home and have a better squad.
Pep Guardiola’s side are on a roll in the Bundesliga and are one of the top three favourites to win the Champions League this season.
Arsenal are also playing well at the moment and are in good form, but the most they can hope for in Munich is a draw.
Arsene Wenger’s side simply cannot afford to concede an early goal, or they could lose by a big margin.