Manchester City manager Manuel Pellegrini had high hopes that his attacking midfielders David Silva and Samir Nasri would return for Manchester City's away match against Sevilla, but it is now looking increasingly unlikely that both of the players will lose their respective battles ahead of the Champions League Group D clash.
The match in Seville is the biggest game of City's season so far, and the Citizens can wrap up qualification to the knockout phase of the competition if they take three points off the La Liga team, and if Juventus either beat or draw with Borussia Monchengladbach, as is widely expected.
Pellegrini had hoped to welcome back both players for the tie, but Silva, who has been absent since suffering an ankle injury whilst on duty with the Spanish national team, and Nasri, who aggravated a hamstring problem in City's 5-1 win over Bournemouth, will require more time on the sidelines.
"There was no David Silva or Samir Nasri (at training), meaning the creative duo are unlikely to travel later today," a statement published on Manchester City's official club website said.
It was not all gloom and doom for Manchester City, however, as two other absentees were revealed to be on the plane to Spain.
English international Fabian Delph could be in line for his first ever Champions League appearance after a lengthy spell on the sidelines with two separate hamstring complaints.
After making a bad-tempered summer transfer from Aston Villa, with supporters of the Midlands club accusing their former captain of renegading on his promise to stay, Delph has played just 16 minutes of football for his new club and has struggled to maintain fitness.
He will be joined on the flight to Seville by defender Gael Clichy, who has missed the whole of the current season with an ankle problem.