Indeed, while the Arsenal man has faced all sorts of rivals in the Premier League, Champions League and domestic cups - along with his exploits on international duty with Wales - no one has made as much of an impression on the 24-year-old as Parker.
When asked about his toughest ever opponent, the Arsenal midfielder told Uefa: "Scott Parker. He doesn't give you a moment's rest on the ball and is always kicking away at your ankles or tackling you. He is definitely the toughest opponent I've played against."
Parker has been at Fulham since leaving Tottenham in 2013 but Ramsey's memories of the 35-year-old at his toughest likely stem from his time at Spurs - during north London derbies.
Parker's career is an interesting case - he has captained England and played for Chelsea but he was never considered one of the top midfielders of his time.
At Tottenham, Parker was well respected for what he did. And, as Ramsey says, few can pressurise an opponent quite like the Fulham man. In the end, though, Parker's age got to him to a degree, while he was always slightly limited when it came to the top level.