It is Steve Evans' first game in charge at the stadium, and he will be desperate to build on his two away draws at Fulham and Bolton with a victory.
Here is a look at how the two teams line up for the fixture...
Leeds United line-up: Silvestri, Byram, Cooper, Bamba, Berardi, Dallas, Adeyemi, Murphy, Cook, Antenucci, Wood
Substitutes: Horton, Bellusci, Wootton, Mowatt, Buckley, Botaka, Doukara
Blackburn Rovers line-up: teele, Marshall, Duffy, Hanley, Olsson, Taylor, Evans, Akpan, Conway, Lawrence, Rhodes.
Substitutes: Raya, Henley, Spurr, Kilgallon, Delfouneso, Williamson, O'Sullivan
Leeds are also still searching for their first goal from open play under Evans, with both strikes in their first two games coming from the penalty spot.
The match is a big one for both teams in terms of league position. The Whites are in 17th place in the table, with Blackburn one place and one point behind them.
Leeds have not won a home game all season while Blackburn have not recorded a victory away, and are coming off a disappointing 1-0 defeat to rivals Burnley at the weekend.