Arsenal are hoping their recent winning run does not end against Championship side Sheffield Wednesday on Tuesday evening.
A week on from beating Bayern Munich, Arsene Wenger has to select a team he feels is capable of handling a cup tie atmosphere, while also wanting to rotate his squad.
Wenger has already been drip-feeding his team selection, confirming three of the players who will start the game at Hillsborough.
One is goalkeeper Petr Cech, with a lack of viable alternatives even if he did want to rotate. Wenger told Arsenal's official website: "Ospina is still out too, so Cech will certainly play."
That has to be good news for if there was one thing likely to bring about an upset it would be a goalkeeping error, and of the options available Petr Cech is least likely to make one.
Two more confirmed starters, according to Wenger, are out of favour Costa Rica international Joel Campbell, and back-up defender and England under-21 star Calum Chambers.
He told Arsenal.com: "When you get the chance, you have to be ready. To be ready, you have to prepare. I must say that Joel Campbell and Calum Chambers are two players who do absolutely everything right.
“They are prepared, the preparation they have created will give them the confidence against Sheffield Wednesday and I’m confident they will play well."
In addition to Ospina, Arsenal's injury list currently comprises of Aaron Ramsey, Mikel Arteta, Jack Wilshere, Tomas Rosicky and Danny Welbeck.