West Bromwich Albion face Norwich City on Saturday.
Morrison has been suffering with an ankle injury, which he picked up over the international break, and his recovery has not been as quick as the Baggies would have hoped.
The midfielder participated in training on Thursday, but his ankle was still proving problematic, and Pulis admits he is disappointed to be without the 29-year-old.
"James is struggling, and that's a disappointment because he has got that quality that we need to open teams up," he said.
"He's been away with Scotland and little bits and pieces like that don't help your team.
"We'll see, he trained yesterday but I still don't think he was comfortable so we'll have a chat today."
Morrison has been a key player to date this season, and had played in every one of the Baggies' matches prior to his injury.
The Scotland international's absence has given other members of Albion's squad the chance to step up, though, and Stephane Sessegnon took his opportunity in the Baggies' most recent outing.
It seems that Pulis is now set to keep faith with the Benin international, with the Welsh boss hinting that he will start against Norwich.
"If I was Sess I'd be really disappointing if I didn't play on Saturday," he added.