Flying winger Victor Moses is ineligible to face his parent club, while key defender Winston Reid misses his second consecutive game.
Meanwhile, Chelsea have endured a much-publicised torrid start and are currently languishing in the unfamiliar territory of 12th place.
But what are the omens like for the Hammers going into the game?
Well history is on the Hammers' side, with the East Londoners having the better of the 47 meetings at the Boleyn Ground over the years.
If the history books are anything to go by, there will be plenty of goals. In the 47 games there have been a total of 147 goals, an average of more than three per game.
West Ham's biggest ever win over the Blues also came on home soil, a 5-3 victory in the 1986/87 season.
Under Sam Allardyce last season, the Irons lost the home fixture 1-0 but were extremely unlucky not to have won the game let alone draw with chance after chance going begging.
Bilic's side are a different outfit, though, and will pose a real threat as they are the Premier League's second highest goal scorers behind leaders Manchester City.
Their results at home have not been as good as their league-best away form, though, and that will need to change if Bilic's side want to pull off a win that would take them onto 20 points from the first 10 games.