He will have to make changes to the team which beat Crystal Palace 3-1 last time out, though, because loan star Victor Moses is ineligible to play against his parent club.
One thing about West Ham this season, though, is that for once they have the squad to cope.
But with a wealth of options available comes selection headaches.
So we asked Hammers fans who they thought should replace Moses in the side in a HITC.com poll.
Hammers fans have spoken
And the Upton Park faithful have spoken by voting overwhelming for Antonio, a summer signing from Nottingham Forest, to be given his full home debut against the Blues.
Antonio secured 43% of the vote, with fit again Enner Valencia second with 36%.
Eleven per cent think Mauro Zarate should step in after he played a crucial role in West Ham's winning goals against Palace last time out. Pedro Obiang and Andy Carroll were next, both getting 5% of the vote each as the player Hammers fans think should step into the fold.
There was one player the fans clearly don't think should replace Moses, though, with another summer signing Nikica Jelavic getting just one vote from 710 cast.
Logical but unlikely
While Antonio would be the logical replacement, given how similar he is to Moses as a player, he is actually the least likely to come in.
That's because he has only featured once as a substitute since signing from Forest.
Many fans think he was brought in to be a natural successor to Moses when his loan deal expires next summer.
A very similar player who is blessed with pace, skill and an eye for goal, Antonio would be a surprise inclusion which may catch Blues boss Mourinho on the hop.
However, he was left out of West Ham's squad altogether last time out against Palace, so that looks unlikely.
Meanwhile, Chelsea have endured a torrid start and languish in 12th place.