The injury-plagued England striker was once again absent for the Reds on Saturday as the Jurgen Klopp era began with a creditable goalless draw away to Tottenham Hotspur on Saturday.
Klopp had to pick the first XI of his reign without the likes of captain Jordan Henderson, Dejan Lovren, Christian Benteke and Roberto Firmino, but it was the absence of Sturridge that was perhaps felt the most at White Hart Lane.
The raw and inexperienced Divock Origi toiled to little effect up front, and Sturridge's continued problems with injuries was a big factor behind the club's decision to spend £32 million on Benteke from Villa back in the summer.
Since netting 21 Premier League goals in the 2013-2014 campaign, Sturridge has been beseiged by injury troubles, with a succession of hip, calf and thigh problems limiting him to just 12 appearances in the division.
Despite being 26, Sturridge has made just nine more appearances in league action than former teammate Sterling, who turned 20 back in December.
Daniel Sturridge's injury problems: 94 career league starts, aged 26. 85 for Raheem Sterling, aged 20.— Daniel Storey (@danielstorey85) October 19, 2015
Sterling, who left Anfield for City for an eye-watering £49 million back in July, made his maiden bow in England's top division back in 2012 when he appeared against Wigan Athletic.
Kenny Dalglish put Sterling in against the Latics to see the 17-year-old become the third youngest player to represent the 18-time English champions in the process.
A knee injury was the latest issue to keep Sturridge out of the side against Spurs, but the Reds are hopeful of having the striker back in time for the visit of Rubin Kazan in the Europa League on Thursday.
Sturridge has made just two appearances for the Reds this term, and starred in a 3-2 win against Aston Villa last month, scoring twice with two classy finishes, and the England hitman has the best goals to games ratio in Premier League history for Liverpool.
Since joining from Chelsea for around £12 million in January 2013, Sturridge has hit 38 goals in 58 games, but his continued injury issues have often frustrated supporters.
Sturridge spent the pre-season campaign recuperating in Boston after surgery on a hip issue and Liverpool were privately hopeful that his injury issues were finally put to bed, but after the latest knee problem, fans are understandbly cautious and dubious over the centre-forward's ability to enjoy a prolonged run in the side.