Rangers will head into the game at Loftus Road on the back of a 2-1 defeat to Birmingham City away from home at St. Andrew’s in the league.
The London outfit, who got relegated from the Premier League at the end of last season, are 12th in the league table at the moment with 15 points from 11 matches.
Chris Ramsey’s side are five points behind sixth-place Derby County, which means that they are very much in the running for a playoff spot.
Meanwhile, Wednesday find themselves ninth in the Championship table at the moment with 16 points from 11 matches, four points behind Derby.
The Owls have been playing well recently, but they have kept just one clean sheet in their last 10 away games
QPR are unbeaten in seven home matches against Wednesday, last losing to them at Loftus Road in October 2000.
Queens Park Rangers XI: Green, Onuoha, Hall, Hill, Konchesky, Tozser, Sandro, Phillips, Chery, Luongo, Emmanuel-Thomas
Subs: Smithies, Angella, Henry, Doughty, Fer, Hoilett, Faurlin
Sheffield Wednesday XI: Westwood, Palmer, Loovens, Semedo, Nuhiu, McGugan, Lees, Wiggins, Sougou, Banna, Forestieri
Subs: Wildsmith, Hutchinson, Joao, Lee, Sasso, Wallace, Pudil