The Gunners boss has conceded his side will have their backs to the wall against Bayern Munich.
The Gunners take on Bayern Munich in the Champions League this week needing a positive result to have any hope of making the last 16 after two disastrous defeats in their first two games.
They will have to find a way to stop Lewandowski though with him in red hot form having scored 15 goals in his last seven games for club and country.
He also has history against Arsene Wenger’s side having scored the winner for Borussia Dortmund on his last visit to the Emirates, and Wenger admits they will have to be shrewd with him.
"First of all the best way to combat him is for us to have the ball," he told arsenal.com.
"After that you have to be shrewd with him because inside the box he is outstanding, because of his technique, his finishing, his movement inside the box. We need the experience of Mertesacker and Koscielny to deal with that because that will be one of the important things on the night.”
The manager has also conceded that his side will have their backs against the wall in their crunch Champions League clash.
Pep Guardiola’s side are in sensation form this season as they top the Bundesliga once again, having won nine games out of nine, scoring 29 goals in the process and only conceding four.
Not many are expecting Arsenal to be able to deal with them when they visit the Emirates, but says they have to prove the doubters wrong.
"I must say we have our backs to the wall and we play against a top, top team.
“I can understand the scepticism of people. But we have to prove them wrong. We don’t look at the history. We look at the potential performance on the day. That’s what we try to do. The history doesn’t play the game.”