The centre-back pairing have been superb throughout the campaign so far, and they have ensured that Spurs have conceded just seven times in their first nine Premier League matches.
As a result of Tottenham's defensive excellent, the side have remained unbeaten throughout their last eight matches.
And Thompson said: "They've got it right at the centre-backs. Vertonghen and Alderweireld have been brilliant.
"These two have come together and they have been the rock of what Spurs are building upon. If the opposition aren't scoring many goals, they are not losing."
Alderweireld was brought to Tottenham in the summer transfer window, and the former Atletico Madrid man has made a seamless transition.
The Belgian international has complimented his international counterpart well at the heart of the Spurs' defence, and they have formed a terrific partnership.
Despite being solid, Spurs have lacked a cutting edge this season, though, with Harry Kane struggling for goals.
Kane has scored just once in the Premier League so far, and their failure to take their chances means that they only sit in seventh place in the table, as things stand.