Tottenham Hotspur are without four first-team players for their match against Liverpool at the weekend.
Heung-Min Son, Ryan Mason, Nabil Bentaleb and Alex Pritchard are all on the treatment table at present, and will miss this weekend's match against Liverpool as a result.
It leaves the Argentine manager with limited options to choose from in his squad, and he admits that has caused him a problem.
“Always it’s a problem when you have some players in this situation but we have a big squad, I trust in all the players," he said.
“Sometimes you have to pick, to decide, who is the best player to play in different games, but I’m happy with the squad. Always you want to have all players fit and available to decide who to pick, but this is football and we need to accept the situation.”
Tottenham's success this season has been built around the stability of their line-up, with Pochettino tending not to tinker.
However, he will have no option but to give his fringe players a chance against Liverpool, as so many of his players are out.
As well as the aforementioned injured quartet, Pochettino will have to deal with the suspension that Eric Dier has picked up for accumulating five yellow cards.