The key defensive cog will be missing when the Reds come to White Hart Lane later this month, following Sunday's fixture with Swansea.
Spurs' maintained their record of avoiding defeat since the start of the Premier League season by drawing away to Swansea City on Sunday, but the result came at a cost in relation to their next league fixture.
Tottenham battled back on two separate occasions to secure a 2-2 draw at the Liberty Stadium, with Christian Eriksen scoring superb free kicks after Andre Ayew gave the Swans the lead, and then again after Harry Kane had sliced a clearance into his own net.
But Eric Dier, a player who has become a hugely important part of Mauricio Pochettino's new defensively solid Spurs side, received his fifth yellow card of the season after attempting to tackle Ayew midway through the second half. It means he will be suspended for the club's next domestic game - a match against fellow top four hopefuls Liverpool, who will have a new manager in charge after sacking Brendan Rodgers.
A visibly distraught Dier remonstrated with the referee after he was booked for the challenge on the Ghanian, who was a constant thorn in the side of the visitors with his control and vision. The 21-year-old insisted he won the ball, and was seething after the incident. Undoubtedly, the youngster was aware that he will now miss what looks like being a massive fixture at White Hart Lane on October 17th.
And it's certainly a blow for the Lilywhites, with Dier being the only Spurs man to have started every game for the club this season, with other players being rested for League Cup and European matches at least once when they were available. The defender has adopted superbly to a defensive midfield position, and it has seen the North Londoners tighten up at the back - they currently boast the joint best defensive record in the division.
The likes of Mousa Dembele, who returned against the Swans after an ankle problem, as well as Ryan Mason and Nabil Bentaleb, last season's midfield duo who are also nearing their own injury returns, will look to come in alongside the impressive Dele Alli in what will be Liverpool's first game since dismissing Rodgers.