Tottenham Hotspur take on Monaco in the Europa League on Thursday evening.
Instead, the Argentine is determined to ensure that his side prolong their unbeaten run, which has lasted since the opening day of the campaign, and has promised to pick a strong squad for the trip to France.
"Maybe [Clinton] N'Jie has the possibility to play but first we need to analyse the team and try to pick the best player to win the game," said the 43-year-old.
"We need to keep the momentum. The mentality in the team is what is important and maybe there will be some changes but not too much."
Pochettino's attitude towards the Europa League is different to many other managers of English clubs, who use the competition to rotate their entire side.
The protracted nature of the tournament means it is demanding on players, and can harm their domestic form.
Tottenham, though, are keen to have a European run, and go further than they did in 2014/15, when they were knocked out in the round of 32 by Fiorentina.
Getting out of their group, which contains Monaco and Anderlecht, will be a tough task, though, and Pochettino is clearly keen not to take any risks.