Everton take on Liverpool on Sunday in the Merseyside derby.
The Toffees take on Liverpool in the Merseyside derby on Sunday afternoon, and they should be brimming with confidence following a 3-2 win over West Bromwich Albion in their most recent outing.
Roberto Martinez's side currently sit in fifth place in the Premier League table, and Souness believes that their options from attacking midfield make them favourites against their local rivals.
"Everton will start as favourites, but remember, derby games are notorious for in-form teams coming unstuck."
Naismith and Barkley have contributed seven goals between them so far this season, with the pair in fine form.
Naismith netted a hat-trick against Chelsea, in a memorable show of his talent, while Barkley has stepped up his game this term, and is starting to flourish at Goodison Park.
Liverpool, meanwhile, have made a much slower start to their campaign and the atmosphere around the club is considerably less buoyant.
Despite a win over Aston Villa in their most recent fixture, pressure is mounting on Brendan Rodgers' shoulders and he can ill afford for his side to lose to their near neighbours.