With the South Korean sidelined with a foot problem, there is a number of talented attacking midfielders who will be hoping to step in for Mauricio Pochettino.
The news that Heung-Min Son is set for a spell out of the Spurs team with a foot injury is of course a big blow to both the club and its supporters, but as the old adage goes, every absence is an opportunity for another to make an impression.
And given the South Korean's strong impact since signing from Bayer Leverkusen, his rivals for a starting berth may be very conscious that they need to raise their level.
Below are four players who will hope to get a chance with Son missing, with the club uncertain about when he'll return.
Nacer Chadli - The Belgian was the player ousted by Son's arrival, but he made a positive impression when he appeared from the bench against Manchester City. Chadli also set up the Tottenham goal in the League Cup defeat to Arsenal, and is likely to be the go to man for Mauricio Pochettino while the South Korean international is out, unless one of the three below can change the Argentine's mind.
Clinton N'Jie - The 22-year-old could be given a chance against familiar opposition when Spurs face Monaco, and his versatility in attack, like Son, could mean he is an attractive option. Also did well against City, setting up Erik Lamela, and a big performance on Thursday could see him edge Chadli.
Andros Townsend - In danger of becoming the forgotten man, Townsend will hope he is given a chance against Monaco. He has had precious few minutes this season after an early injury but was very much a big part of Pochettino's squad last season. A frustrating figure for many, will the England man be encouraged to raise the bar to stay in and around the first team. The most natural option to come in on the right if Lamela plays centrally.
Alex Pritchard - Such a shame that he has had injury and fitness problems at the start of the season, Pritchard is missing again for the Europa League match, but is edging closer to returning. The furthest away from the starting lineup right now, but the 22-year-old is supremely talented and should get minutes in the rest of the group stage if he can stay fit.
Spurs have arguably their toughest fixture of their Europa League campaign coming on Thursday when they take on French side Monaco.
The principality club aren't as strong as they have been in recent seasons as a number of big name players have departed, but still possess some excellent players in their line-up.
Quite how much Pochettino will be looking to rest first team players remains to be seen, but there is every chance several of those who will be looking to take advantage of any opportunity Son's injury offers will get a chance to impress.