The former Lyon winger is in line for his first Spurs start against familiar foes.
Mauricio Pochettino’s men head to the principality hoping to build on their comprehensive win over Qarabag two weeks ago, and will line up against a much-changed Monaco team.
The French club have parted ways with the likes of Anthony Martial, Geoffrey Kongdogbia and Aymen Abdennour and are a much less fearsome proposition than they were last season.
Despite the changes, N’Jie is still wary of the threat posed by a familiar enemy.
“I think all the teams from the French league, whenever they play teams from England, are motivated and I know we are going to have a difficult game,” he told the official Spurs website.
“Monaco always defend very well and I think they’re going to play forward and attack, so we know it’s going to be a difficult one.
“They will be at 100 per cent because they are playing against Tottenham, but we are going to be ready physically and mentally.
“Monaco are a good team but I think if we go there determined to win we can be victorious,” he added.
The Cameroonian winger has had to be patient with his introduction at Spurs and has so far made just four substitute appearances.
His latest cameo saw him impress in the 4-1 demolition of Manchester City, and he produced a sublime bit of skill to set up Erik Lamela for the fourth goal.
Pochettino must now be considering handing N’jie his first start - and a Europa League tie in familiar territory seems like the perfect place to do so.