A win for the Reds will take them to the top of Group B, in their first European home game of the season after opening their campaign with a 1-1 draw away at Bordeaux, where many youngsters were given the opportunity to impress.
With the Merseyside derby following on Sunday, it does leave Rodgers with a couple of things to consider - does he go full strength in order to win the game, or does he make several changes ahead of the biggest domestic fixture of the season so far?
There are plenty of players who haven't had a chance to get minutes under their belt so far this season, so the Reds boss may lean towards the latter.
Aldridge wrote in his Liverpool Echo column: "He's got players there, the likes of Origi, Ibe, Lallana, Allen who would welcome the game time.
"You could look and say someone like Sturridge could probably do with the match practice, 60 minutes maybe, but I imagine Brendan will have one eye on Sunday with him, and he might sit it out.
"First and foremost, we want to win on Thursday. The carrot is there for the Europa League now; you get a Champions League place if you win it, so you need to be taking it seriously."
Joe Allen is certainly a player looking to get back to fitness, and given the absence of Jordan Henderson, another central midfielder getting up to speed would be welcome, but Jordan Rossiter and Pedro Chirivella will be pushing for a game after their impressive performances against Bordeaux.
There were eight changes made for the game in France, as several first-team players were left on Merseyside, but there is an opportunity to rotate the side and let certain players get a game. Adam Lallana could do with some competitive action, and will be keen to build on his solitary goal for the club, while Divock Origi has yet to have the opportunity to shine, and Rodgers may want to protect the strike duo of Danny Ings and Daniel Sturridge ahead of the weekend derby clash.
The Europa League game is certainly one Liverpool should look to win, and win well as they could do with building some momentum behind them and securing their passage to the knock-out stages of the competition as quickly as possible.