Spurs welcome the league leaders to White Hart Lane ob Saturday.
The London Evening Standard report that City's Spanish schemer was sent for scans during the week after suffering muscle spasms and is unlikely to be rushed back into the side with next week’s Champions League encounter with Borussia Monchengladbach in mind.
Silva has been instrumental in City’s excellent start to the campaign and his absence is a boost for a Spurs side who have struggled to compete with the Blues in recent encounters.
The Lilywhites have failed to get the better of the Citizens for over two years, and have conceded 16 goals in the last four encounters.
Meanwhile, Spurs midfielder Ryan Mason is due to return after taking a knock as he converted the winning goal against Sunderland two weeks ago.
The Spurs academy graduate had begun to form a promising partnership with midfield enforcer Eric Dier, and Mauricio Pochettino will be keen to reunite the pair.
The difficulty now faced by the Spurs boss is how to fit the likes of Dele Alli, Heung-Min Son and Christian Eriksen into the team together, but it will come as a welcome problem after the lack of options available at the start of the season.