Paul Merson says Tottenham face getting badly beaten at home
The two clubs face off at 12.45pm on Saturday, with Spurs looking to bounce back from a midweek loss at home to rivals Arsenal.
The former Gunner believes the Capital One Cup loss will be a decisive factor in this weekend's result, with City getting back on track themselves with a 4-1 away win at Sunderland.
He said: "This will be a walk in the park for City, especially after their slip up against West Ham.
"Spurs' north London derby defeat will affect them, especially as they were looking for a winner when Mathieu Flamini banged in the second.
"I can't think of a tougher game for them, and I see this as the game Sergio Aguero comes back to scoring ways in the league."
Merson predicted City will win 3-0 against Spurs, with Harry Kane's goalless streak set to continue.
City had lost their last two home games, to Juventus and West Ham, and playing away from home is likely to suit them.
Aguero has a stunning record of 109 goals in 172 games for Manchester City, and an even more impressive ratio against Spurs - He has 10 goals in 7 games against Tottenham so far in his career, scoring more times against them than any club in England or Spain.