The fixture was viewed as welcome respite from the Premier League and a chance to gain some much needed confidence, but events transpired much differently.
An insipid Magpies team failed to threaten enough against an Owls side that had made 10 changes from their win against Fulham at the weekend.
Lewis McGugan’s powerful strike from the edge of the box in the 76th minute proved to be the difference as Steve McClaren’s men struggled in front of goal.
Siem de Jong managed Newcastle’s first shot on target in the 85th minute, as a team currently positioned in the bottom half of England’s second tier outfought and outplayed their top flight counterparts.
The Magpies left the field to boos and things don’t get any easier with Chelsea's visit to Tyneside next, followed by a trip to Manchester City.
Newcastle fans were dismayed at their team’s latest setback and took to Twitter to share their thoughts on another tough night at the office:
Another woeful performance against a weakened Sheffield Wednesday side. Lack of effort is digusting. Something needs to change #NUFC— Rob M (@geordierob89) September 23, 2015
Says a lot when you genuinely aren't surprised or bothered that you've lost to Wednesday's reserves. Lol, #nufc that.— Stan (@Henry_Staniland) September 23, 2015
Give the bloke some time it doesn't just happen over night, he's still dealing with Pardew ans Caver's mess. #NUFC— Jordan (@NufcJordy) September 23, 2015
One good thing about us not being in the cup is we can now focus more on losing in the league... #NUFC— Bushby (@supertintin96) September 23, 2015
Don't worry, we've still got the disappointment of being knocked out of the FA Cup to come. #NUFC— Trev Walker (@_Trevaldo) September 23, 2015
That team was more than strong enough to win tonight. The core of the team is rotten. Upheaval was needed in summer . not enough done #NUFC— Niallers (@Nufcniallers) September 23, 2015
I'm giving up on #nufc and taking up crack, it's got to be cheaper, less stressful and at least there might be a moments enjoyment with that— James Sharp (@sharpy262) September 23, 2015