The Tottenham Hotspur defender has been out of the first-team picture all season.
Of all the members of Tottenham's team so far this campaign, Federico Fazio has perhaps been sent the clearest message of all when it comes to his squad status.
With Jan Vertonghen and Toby Alderweireld the north London side's first-choice centre-back pairing by miles, the Argentine can only dream of a Premier League start right now.
Behind the main duo, though, sit Kevin Wimmer and, if need be, Eric Dier - currently starting in central midfield.
Fazio, meanwhile, after a poor first season at Tottenham, didn't even feature in the Europa League against Qarabag last week, when many thought he would.
At this rate, there is little point in the 28-year-old being at Spurs. In January, he may well be out the door of his own accord if his lack of minutes continue.
A lot will depend on whether Pochettino sends out a second-string side against the Gunners, of course. But, if so, why not give Fazio a go?
The 28-year-old needs some sort of match sharpness, otherwise any Premier League clash he might be needed for during a hypothetical injury crisis will end up a waste of time for the Argentine.
And playing Fazio against Arsenal will provide the centre-back with a big challenge. If he wants a place in the Tottenham side, he'll have to earn it the hard way. If he can't handle the pace, he'll have another reminder of why he's not in the XI.