Tottenham Hotspur take on Arsenal in the Capital One Cup on Wednesday evening.
Spurs are competing domestically and in Europe, and their demanding schedule means that the Argentine head coach is eager to rotate his squad.
Pochettino says that he could make a number of alterations to his side in midweek, but insists that the line-up he picks will be capable of winning the tie against Spurs' North London rivals.
"We have a squad that is full of important players," he said. "We have some injuries, and we will rotate the team in different games.
“You can see that when we played Manchester United, the players who started in that game were different to the ones that played against Crystal Palace.
“You need to translate the confidence in your squad and I trust my squad. the players that can play tomorrow I have no doubts will do best their best for the team.”
Pochettino may want to make changes, but he will also have to be cautious - as he won't want to disturb the momentum his side have established.
Tottenham are unbeaten since the first game of the season, and they go into their match against Arsenal having won their last three matches.
It means that they will be confident of picking up a result in front of an expectant White Hart Lane crowd, with local bragging rights and a place in the fourth round of the League Cup up for grabs.
If Pochettino does make changes, then the likes of Clinton Njie, Ryan Mason and Kieran Trippier could be among the players in Tottenham's squad to benefit.