The Belgian is set to be rested for Wednesday's League Cup clash with Arsenal.
Cup competitions usually bring about wholesale changes for Spurs, and Wednesday's League Cup clash with bitter rivals Arsenal will likely see a shuffling of the pack.
“I want to play every game because I like to play football, but sometimes it's better for me to rest,” said Vertonghen, in an interview with Sky Sports.
"I think it's good that the medical staff and technical staff make that decision for you. You can still be fresh in March or April that way."
"In the league we have Manchester City, Swansea and Liverpool coming for us, and in the Europa League we want to involve all the players. We have a big squad and it was very important to win to go into Arsenal on Wednesday.”
Vertonghen’s words suggest he will be replaced by Kevin Wimmer – as was the case against Qarabag last week – but the lack of a trusted alternative at right centre-back means Toby Alderweireld will likely start his eighth competitive game for Spurs against Arsenal.
The likes of Kieran Trippier and Danny Rose will expect a run out, while Ryan Mason, Mousa Dembele and Christian Eriksen could all feature after recovering from injury.
New boy Clinton N’Jie will be eyeing a first start and Pochettino will be reluctant to take the in-form Heung-Min Son out of the side.
Rotation is a wise and logical move for a squad of players, but only one of sufficient quality. Spurs struggled last season when calling upon their reserve players, but now look in far better shape to compete on multiple fronts.