Sunderland are looking to stumble upon a successful formula, after making a disappointing start to the season.
And, as a result of their poor form, Advocaat now wants to use the League Cup as a competition to experiment with his team.
“We will play a little differently in the line-up so I have to take a look at some players and how they do in a different position – a normal position for me but different to what I did before," he said.
“We have nothing to lose tomorrow night, in my opinion, against a top European club."
Sunderland's start to the season has raised alarm bells with their supporters, who are worried that they could be in for another relegation fight.
The Black Cats have narrowly escaped the drop-zone in the last two seasons, but Advocaat insists there is enough quality in their team to ensure that they finish higher up the Premier League table this time around.
“We can see in the figures the improvement of the players physically and we’re coming to a level where there are no excuses anymore," he said.
“We are moving in the right direction but as I said if you get new players in the physical condition they came to us it takes time.”
If Advocaat is true to his word and does experiment, then one of the players in line for a start could be Duncan Watmore, after the youngster scored a hat-trick for the club's development side on Sunday.
Sunderland made it into the third round of the Capital One Cup by beating League Two Exeter City 6-3 in their only win of the season so far.