Brendan Rodgers has a decision to make after losing his captain for up to eight weeks.
They have been without their captain for the last three games, and struggled in that time - with consecutive defeats to West Ham United and Manchester United having put them under intense scrutiny early on in the season.
So far, they have sorely missed their skipper's presence in the middle of the park, with many saying Liverpool need to change their formation and personnel to get the best out of those still at their disposal.
We decided to take a look at three ways they could change the line-up to compensate for Henderson’s absence.
First up is a 5-3-2 formation, which sees Rodgers returning to the system he adopted last season.
Choosing this would allow him to bring in both Mamadou Sakho and Daniel Sturridge, and keep the rest of the side happy. At left back, Joe Gomez would likely continue, although Alberto Moreno could be a better option given he is more suited to the wing-back role.
This formation, however, sees both Adam Lallana and Roberto Firmino losing out, with Philippe Coutinho the obvious option in the playmaking role.
Similar to the formation Liverpool adopted for the game against Manchester United, but with one key change.
Moving James Milner into the right wing role would be a more natural choice than choosing Firmino in that position, with the Brazilian more comfortable in a central berth. Playing both Emre Can and Lucas Leiva in central midfield would give Liverpool a solid defensive base and leave the creative influences to focus on their attacking play.
The negative, of course, is that Firmino would once again miss out, while Lallana would be shifted out to left wing, with him also preferring to play centrally if given the choice.
Another formation that sees Milner move out wide, this could be an ideal way to get some width into Liverpool’s side.
The Reds have few wingers in their squad, aside from Jordon Ibe, and this formation would be a perfect way to utilise the youngster. Similarly, it finds a way of getting both Coutinho and Firmino into the starting XI together without compromising on position.
On the negative side, Milner is once again forced out to the flanks, while the likes of Lallana and Sturridge are sacrificed entirely. It would also mean potentially more isolation for Benteke, although wingers putting the ball into the box could help to ease that problem.