But with Ogbonna now ruled out for at least three weeks with a hamstring injury - announced on the club's official website - even more responsibility will fall on the New Zealand skipper's broad shoulders.
West Ham were one of the busiest clubs over the summer, signing 12 players with a net outlay of around £35 million.
Reid the best signing of the lot
However, many Hammers fans will tell you their best bit of business was done back in March when, after over a year of speculation linking him with some of Europe's top clubs, Reid signed a new six-and-a-half-year deal in East London - as covered by the BBC.
The 28-year-old Kiwi star will be playing his 129th West Ham match at City but it will have to be one of his best if Slaven Bilic's side are to get a result.
City are the Premier League's top scorers and boast a 100% winning start to the new campaign five games in.
But the Hammers are in good form too, thanks in no small part to Reid, who has helped his side to keep three clean sheets in wins at Arsenal, Liverpool and against Newcastle United last time out.
Ogbonna's place in the West Ham defence will be filled either by James Tomkins or James Collins, both players Reid has played with on numerous occasions in the past.
If anyone can, Winston can
City hitman Sergio Aguero looks likely to be fit after limping off in the Blues' win over Crystal Palace last weekend.
Not many can handle the red hot Argentinian, but Reid has all the attributes to cope with the ruthless striker.
While the New Zealander excels in aerial battle, he is one of the Premier League's finest on the deck, using his pace and power to great effect on a regular basis.
The odds are stacked against the Hammers in this one, but if Reid puts in another nine or 10 out of 10 display, anything is possible.