Luke Shaw's horror injury has come at the wrong time for both Manchester United and England.
After a season full of injury problems last time out, the 20-year-old started this campaign in simply incredible form.
But the Manchester United man's injury could well prove someone else's gain...
With Shaw out for a potentially lengthy period indeed, West Ham United's Aaron Cresswell is in pole position to profit. England boss Roy Hodgson has simply neglected the 25-year-old to date - but the excuses will be running thin in terms of ignoring him now.
The simple fact is Cresswell's two main rivals for Shaw's spot are both currently not featuring. Tottenham's Danny Rose started the campaign short of fitness and is still being kept out by Ben Davies. Southampton's Ryan Bertrand is also yet to play.
Were both fit, though, the West Ham man would still be the obvious choice for Hodgson. Going forward, there is no one better. And Cresswell's reaction to his horror performance against Liverpool was exemplary, as the left-back simply returned to his usually superb form straight away.
Based on last season's form, many may feel Tottenham's Rose is the man to replace Shaw. This is all assuming Arsenal's Kieran Gibbs would already make the squad (although he should remain on the bench even without Shaw).
Once the 25-year-old does return to first-team action, of course, he may well shine enough for those calls to return. But England call-ups work like a chain. Cresswell is on form now, meaning Hodgson should turn to him for the Estonia game next month. And, if the Hammers defender shines there, the ball will be in his court for the next few games.
Southampton's Bertrand could have a greater advantage than Spurs man Rose as he faces less competition at club level. Hodgson has also turned to him before for the Three Lions, arguably placing him ahead of Cresswell in the pecking order.
The Saints full-back's pre-season injury will put him on the back foot, though, meaning the England manager has no choice but to turn to West Ham's left-back now. If he doesn't, it would be a footballing injustice.