It was the first Champions League game the Spaniard has played in his career, and a real turnaround for a player who was allowed to leave Tottenham Hotspur a year ago without making a single Premier League start.
Falque was sold to Serie A side Genoa 12 months ago where he went onto impress, scoring 13 goals and providing three assists, earning a switch to Roma.
He started last night on the left wing, playing 82 minutes in the draw which will be remembered for a long range goal from his teammate Alessandro Florenzi.
Falque had one shot at goal, but struggled to make his mark offensively, completing only 60 per cent of his passes.
Most of his good work was done off the ball, with Roma boss Rudi Garcia singling his contribution out after the game.
Falque explained after the game that he had to play a more unusually defensive game, due to Barcelona's strength.
Football Italia reported that he told Roma TV: "I am pleased with the faith Rudi Garcia has in me. I do what he asks on the pitch, though it wasn’t my sharpest game in attack tonight because Barcelona really force you back.
“It’s easy to settle in and play good football with these teammates. I had to go deeper than usual, as Leo Messi always had the ball, so I had to help out Lucas Digne."
Falque did not look out of place on a pitch adorned by stars, and he will only take more confidence from it.
He was a regular goalscorer for Tottenham's under-21 side, and it really seems as though the club missed a trick in not pushing him for a first team spot.
His progress at the club was evidently not helped by constant changes of head coaches, and by time Mauricio Pochettino arrived, Falque wanted first team football.
The decision he made to leave the club clearly appears to have paid off, judging on his rapid progress since.
Here is a look at how Tottenham fans reacted to seeing their former under-21 star mixing it with the likes of Lionel Messi...
Iago Falque not good enough for Spurs but good enough for Roma against Barca. Great business there— Elliot Fernley (@elliot_fernley) September 16, 2015
Iago falque now a starter at Roma but never at Spurs ......hmmmm— Giorgio (@TottenhamSpur) September 16, 2015
Who would have thought Iago Falque would be facing Barcelona in the UCL after we gave up hope and disregarded him...oh yeh its typical Spurs— Jacob. THFC (@jmistry11) September 16, 2015