A win for the Whites would lift them above tonight's opponents in the Championship table.
Ipswich were beaten heavily by Reading on Friday night, but the turnaround in the Championship will be a quick one for them when they make the trip to Elland Road this evening.
After being beaten by five goals to one last time out, they make the trip North with a point to prove, though perhaps equally vulnerable following their shock defeat against Reading.
Here are three areas where Leeds may be able to prolong the skid of Mick McCarthy's team:
1. Stuart Dallas vs. Luke Chambers
Leeds' left winger is in good form at present, and growing into his new role at the club with each passing week. His drive and determination has been a real asset for Uwe Rosler's team so far.
This evening, he will come up against Luke Chambers at right back; a very good defender in his own right, but one who Ipswich will be trying to protect against one-v-one's given Dallas' agility. The reverted centre back will need some assistance on his side of the pitch.
2. The usage of Mirco Antenucci
The Italian striker has been in excellent form at the start of the new campaign, even if most of his opportunities have had to come from the bench. Whether he gets his desired start or not this evening, Antenucci will still have a part to play in Leeds' attacking intent.
Rosler's preferred lone forward, Chris Wood, struggled against Brentford's imposing centre back pairing on Saturday, while he will come up against a similarly aggressive pair in Tommy Smith and Christophe Berra this evening.
If Antenucci starts alongside Wood in a 4-4-2, his irritability and dynamism will help to alleviate the attention paid on his partner. If he comes off the bench again, his intent on the ball against a team who are more suited to defending against a direct style of play could cause problems.
3. Getting Lewis Cook beyond Ipswich's midfield
With McCarthy's team expected to employ their favoured 4-4-2 system again at Elland Road, getting midfielders to join attacks will be vital for Leeds if they're to break their opponents down. And a key man in that will be young midfielder Lewis Cook.
The 18-year-old possesses a startling burst of pace, and if he can get in behind the midfield duo of Cole Skuse and Jonathan Douglas to put Ipswich's defence on their heels, he will have opportunities to make some defining attacking actions.