United suffered a 2-1 defeat to Swansea City before the international break, and Louis van Gaal will certainly be desperate to see his side hit back with a victory.
Tonight's clash against fierce rivals Liverpool couldn't be a better opportunity to do just that, with the Reds also coming off a defeat following a 3-0 home thrashing by West Ham United.
Liverpool weren't busy before the transfer deadline, but Manchester United shocked the world by signing Monaco forward Anthony Martial, and the Frenchman could make his debut this evening.
However, the biggest boost to the Red Devils may come in the form of goalkeeper David de Gea, who has extended his contract at Old Trafford after a summer of speculation surrounding his future.
Now, former Tottenham boss Redknapp has used Kicca to predict a Manchester United win - and believes that Spanish international De Gea will be a 'big difference' for Van Gaal's men.
"I think Man United will beat Liverpool tonight – De Gea staying will be a massive boost for the whole club, he makes a big difference," said Redknapp.
It's unclear whether De Gea will start the game this evening, but his decision to sign a new four-year deal has certainly given United fans a major boost, and Old Trafford should be rocking for the visit of their biggest rivals.