Clyne appears to want aggression from the Reds as they try and land an early-season blow on their fierce rivals.
The Reds are looking to bounce back from a disappointing, and humiliating defeat at the hands of West Ham United before the international break, but the Reds know that they can move ahead of their fierce rivals in the top-flight standings with a win on Saturday evening.
Clyne told the official Liverpool website: "Working hard, playing on the front-foot and taking the game to them is going to be key. We can’t allow them to pass the ball around as they like to or have too much free space.
"We need to be at their throats from the start, not let them settle in the game, and with the quality we have up front we can cause them problems."
Liverpool will want to improve on their goalscoring haul from the opening four games, having only found the net on two occasions, but a performance in the same vein as the first half display of the goalless draw against Arsenal - with goals added for good measure - seems to be the kind of thing that Clyne wants to see from the Reds.
Though the Reds will look to be aggressive and get on the front foot, they will need to be tight at the back - like they were in their opening games - if they are to come away with a positive result - much like the game that Clyne played in last season at Old Trafford, when the Southampton side he was part of came away with a 1-0 victory.
It was a case on not giving their opponents many chances, but taking the opportunity that was presented to them. Something like that will be just what Liverpool need to calm any recurring fears regarding the Reds defence, and possessing some attacking potency at the opposite end would show some flicker of progress.