The Reds will be looking to return to winning ways in the Premier League on Saturday when they take on United away from home at Old Trafford.
Liverpool will head into the game on the back of a 3-0 defeat to West Ham United at Anfield before the international break.
Belgium international striker Benteke, who joined the Merseyside outfit from Aston Villa in the summer transfer window, is expected to lead the line for Brendan Rodgers’s side on Saturday.
Former England international striker Owen, who played for both Liverpool and United, has backed the 24-year-old to create problems for the Red Devils’ centre-backs.
"He's the modern type of striker,” the 35-year-old wrote on Premierleague.com. “He can lead the line. He's big, he's strong and can bring others into play.
“He can score with his feet and his head. As a lone striker he will certainly occupy both centre-backs."
Benteke is regarded as one of the best strikers in the Premier League, but the former Genk and Villa star has yet to show his true quality for Liverpool this season.
The Belgian has scored just one goal in four Premier League appearances for the Reds, although he has created seven chances.
The 24-year-old has a pass accuracy of 63% and a shot accuracy of 50%, and has won 40 headers, four dribbles and one tackle.