Both sides are under new managers, with hosts West Ham having won two of their opening four Premier League fixtures under Slaven Bilic and the Magpies drawing two and losing two so far under Steve McClaren.
The Hammers pulled off big shocks with superb away wins on the opening day at Arsenal 2-0 and then last time out 3-0 at Liverpool, their first victory at Anfield in 52 years.
Sandwiched in-between were two poor home results, a 2-1 defeat to Leicester City and 4-3 reverse against newly-promoted Bournemouth.
Newcastle started the season with a 2-2 draw at home to Southampton and followed that up with a 2-0 defeat at Swansea City, a hard fought 0-0 draw with Manchester United at Old Trafford and a 1-0 home defeat to Arsenal last time out.
Newcastle the perfect match to get West Ham's home form back on track?
According to the history books, the visit of Newcastle is the perfect match to get West Ham's home form back up and running for such a historic season.
There promises to be goals, too. From the 61 matches in East London, the sides have scored a total of 172 goals at an average of 2.8 per game. The Hammers have scored 104 of those to Newcastle's 68.
West Ham also have the memories of an astonishing 8-1 win over the Geordies back in the 1985/6 season when they secured their highest ever top-flight finish of third after being pipped to the league title by Liverpool.
The Hammers, then under Sam Allardyce, triumphed 1-0 over Newcastle at the Boleyn last season thanks to Aaron Cresswell's first ever Premier League goal.
After months out with a serious injury, Andy Carroll is set to make his Hammers return against his boyhood club.
Is it fate? The big striker will more than likely start from the bench and enter the fray late on, but we've seen it countless times before in the Premier League when the homegrown star returns to haunt his old club.
You wouldn't bet against it.
They played for both: Players that have represented West Ham and Newcastle
A number of notable players have played for both West Ham and Newcastle over the years and here we take a look at some of the prestigious names on that list.
Bryan 'Pop' Robson, Stuart Pearce, Paul Kitson, Wayne Quinn, Rob Lee, Craig Bellamy, Kevin Nolan, Andy Carroll, Shaka Hislop, Scott Parker, Keiron Dyer, Lee Bowyer, Nobby Solano, Les Ferdinand, Demba Ba, Abdoulaye Faye.