Spurs added five new players to their squad over the summer, but manager Mauricio Pochettino was seemingly keen to add Wanyama to his side in a bid to offer protection for his defence, as reported by the Daily Mail.
However, the Saints kept hold of Wanyama past the transfer deadline, and are keen to prevent him reuniting with former boss Pochettino in the future too.
The Telegraph suggest that Southampton are so angered by Tottenham's transfer tactics - submitting low bids late in the transfer windows - that they are likely to refuse any future negotiations with the White Hart Lane club.
The most concerning aspect of the report from a Spurs point of view is that a number of other clubs are also frustrated with Tottenham chairman Daniel Levy.
It's stated that West Brom were dismayed by Levy's bids for striker Saido Berahino, whilst West Ham were also put off future deals with Spurs over Levy's reluctance to pay a portion of Emmanuel Adebayor's wages should he move to Upton Park - despite agreeing such terms with other clubs.
Manchester United have reportedly also been reluctant to deal with Levy since signing Michael Carrick and Dimitar Berbatov, all of which will be a huge worry for Spurs fans who often criticise Levy for his transfer policy.
With concerns over dealing with Spurs in terms of sales and purchasing players, Tottenham may end up being forced to do most of their transfer activity abroad - as they did this summer.